Can Spironolactone Cause Weight Gain? Let’s Clear It Up

Spironolactone is widely prescribed for hormonal acne, PCOS symptoms, and even hair loss—but many women pause before starting it, wondering: Can spironolactone cause weight gain?

At Oana Health, we believe in empowering women with facts—not fear. Let’s break down what spironolactone really does in your body, and whether it’s likely to affect your weight.

What Is Spironolactone and How Does It Work?

Spironolactone is a potassium-sparing diuretic—meaning it helps your body get rid of excess sodium and water, without losing potassium. But in women’s health, it’s most often used off-label to block androgens (male hormones like testosterone) that can contribute to:

• Hormonal acne
• Unwanted facial hair
• Scalp hair thinning
• PCOS-related symptoms

By blocking androgen receptors, spironolactone reduces oil production and helps balance hormone-driven skin and hair issues.

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So... Can It Cause Weight Gain?

Here’s the truth: weight gain is not a common side effect of spironolactone. In fact, because it’s a mild diuretic, some people actually experience a bit of water weight loss at first.

However, individual experiences can vary. Some users report bloating or fluid shifts, especially in the first few weeks. This can feel like weight gain but usually isn’t associated with fat gain or long-term metabolic changes.

If you notice significant changes in weight while taking spironolactone, it’s worth checking in with your healthcare provider to rule out other causes—like diet, stress, thyroid function, or changes in physical activity.

What You Can Expect from Spironolactone

Most women take spironolactone for hormonal issues and start to notice clearer skin, fewer breakouts, reduced facial hair, and less oiliness within 2–3 months. And at Oana Health, we make this care easy and affordable.

You can get Spironolactone prescribed online through Oana Health after a virtual consultation with one of our licensed providers. No in-person visits, no pharmacy lines—just personalized care delivered to your door.

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