Does Spironolactone Cause an Acne Purge? What to Expect When Starting Treatment

Spironolactone has become a go-to treatment for hormonal acne in adult women—but if you've just started taking it and notice a flare-up, you're not alone in asking: Does spironolactone cause an acne purge?

At Oana Health, we specialize in hormonal care for women, and we’re here to help you understand what’s happening and how to navigate the first few weeks of treatment.

What Is an Acne Purge—and Does Spironolactone Trigger One?

An “acne purge” refers to a temporary increase in breakouts when starting a new acne treatment. This typically happens when a medication speeds up skin cell turnover, bringing underlying clogged pores to the surface faster than usual.

While purging is more common with topical treatments like retinoids, some women do experience a mild purge after starting spironolactone—especially if the acne is deeply hormonal or cystic in nature.

Why It Might Happen

Spironolactone works by blocking androgen (male hormone) receptors, which helps reduce oil production and hormonal breakouts. In the beginning, your hormones may still be adjusting, and your skin might “push out” some congestion before things stabilize. This adjustment phase can last a few weeks to a couple of months.

‍

‍

The Good News: It Gets Better

Most women see noticeable improvement in their skin within 8 to 12 weeks. Spironolactone doesn't just mask symptoms—it helps stop hormonal acne at the source. At Oana Health, we often combine spironolactone with supportive treatments like anti-inflammatory skincare or gentle topical prescriptions to help reduce the risk or severity of any purge.

Get Spironolactone—Affordably and Online

You can access Spironolactone at Oana Health for affordable prices, with no need to visit a dermatologist in person. Our licensed clinicians provide online consultations, lab testing if needed, and personalized hormonal treatment plans—all delivered to your door.

So yes, spironolactone can cause a short-term purge in some women, but it’s typically a sign that the medication is starting to work. With the right guidance and patience, clear skin is absolutely possible.

‍